100637-60-3 Usage
Description
(3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL)ACETIC ACID is a chemical compound belonging to the benzothiazine class, characterized by a 4H-1,4-benzothiazin-4-yl acetic acid derivative with a carbonyl group at the 3-position and a carboxylic acid group. (3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL)ACETIC ACID possesses unique biological activities and has garnered significant interest in medicinal chemistry and drug discovery due to its potential pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
(3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL)ACETIC ACID is used as a protonophore for its ability to disrupt the proton motive force in bacterial cell membranes, making it a promising candidate for the development of new antibiotics.
Used in Tuberculosis Treatment:
In the field of tuberculosis treatment, (3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL)ACETIC ACID is utilized as a key component in the development of novel drugs, demonstrating potent inhibitory activity against Mycobacterium tuberculosis.
Used in Bacterial Infections Treatment:
(3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL)ACETIC ACID also shows potential in the treatment of other bacterial infections and diseases, further expanding its applications in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 100637-60-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,6,3 and 7 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 100637-60:
(8*1)+(7*0)+(6*0)+(5*6)+(4*3)+(3*7)+(2*6)+(1*0)=83
83 % 10 = 3
So 100637-60-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO3S/c12-9-6-15-8-4-2-1-3-7(8)11(9)5-10(13)14/h1-4H,5-6H2,(H,13,14)/p-1
100637-60-3Relevant articles and documents
Synthesis, characterization and pharmacological activity of 4-{[1-substituted aminomethyl-4-arylideneamino-5-sulfanyl-4,5-dihydro-1H-1,2,4- triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-ones
Gowda,Khader,Kalluraya,Shree, Padma,Shabaraya
experimental part, p. 4100 - 4106 (2011/11/12)
A new series of Schiff and Mannich bases derivatives (6) of 4-[(4-amino-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]-2H-1,4-benzothiazin-3(4H) -one (4), derived from (3-oxo-2,3-dihydro-4H-1,4-benzothiazin-4-yl)acetic acid (3) were synthesized. The structures of all newly synthesized compounds were elucidated by elemental analysis, IR, 1H NMR and mass spectral data. Synthesized compounds were evaluated for their anti-inflammatory and analgesic activity. Among the tested compounds, the (3-oxo-2,3-dihydro-4H-1,4- benzothiazin-4-yl)acetic acid (3) possess analgesic activity comparable to that of pentazocine; activity decreased on derivatization of the carboxylic acid group. However the anti-inflammatory activity of (3-oxo-2,3-dihydro-4H-1,4- benzothiazin-4-yl)acetic acid (3) increased by derivatization of the carboxylic acid group and some of the compounds showed anti-inflammatory activity comparable to that of indomethacin.
Synthesis of 2-substituted-N-carboxymethyl-1,5-benzothiazepin-4-ones and -1,4-benzothiazin-3-ones and their evaluation as angiotensin converting enzyme inhibitors
Trapani,Latrofa,Franco,Liso
, p. 107 - 112 (2007/10/02)
The title compounds 7a-d and 8a-e were synthesized and their in vitro inhibitory activity of angiotensin-converting enzyme (ACE) was examined. In general, these compounds possess poor ACE inhibitory activity. Among the benzothiazinone compounds, which are
