1006376-61-9

Basic information

• Product Name: (1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate
• Synonyms: (1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate;Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, ethyl ester,(1R,2R)-;(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid ethyl ester;ethyl(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylate
• CAS NO: 1006376-61-9
• Molecular Formula: C₁₂H₁₂F₂O₂
• Molecular Weight: 226.2192864
• EINECS: 919-127-6
• Mol File: 1006376-61-9.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 262.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.257±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate(1006376-61-9)
• EPA Substance Registry System: (1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate(1006376-61-9)

Safety Data

• Hazardous Substances Data: 1006376-61-9(Hazardous Substances Data)

Usage

Uses

(1R,2R)-trans-Ethyl 2-(3,4-difluorophenyl)cyclopropanecarboxylate is a useful chemical in studying the inhibitory effect on ADP-induced platelet aggregation of ticagrelor derivatives as antiplatelet agents.

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 1006376-63-1 (S)-2-(3,4-difluorophenyl)ethylene oxide 
• 1070-34-4 butanedioic acid, monoethyl ester 
• 14794-31-1 ethyl 3-(chloroformyl)propionate 
• 898752-22-2 C₁₂H₁₂F₂O₃ 
• 623-73-4 diazoacetic acid ethyl ester 
• 405-03-8 1-(3,4-difluorophenyl)ethene 
• 4660-80-4 ethyl (R)-(+)-2,3-epoxypropanoate 
• 451455-95-1 diethyl (3,4-difluoro-benzyl)phosphonate 
• 85118-01-0 alpha-bromo-3,4-difluorotoluene 
• 15333-22-9 4-chloro-but-2-enoic acid ethyl ester 
• 348-61-8 1-bromo-3,4-difluorobenzene 
• 1006376-60-8 (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol 
• 51336-95-9 2-chloro-1-(3,4-difluorophenyl)ethan-1-one 

Downstream Products

• 220352-36-3 trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid 
• 1006376-62-0 (1R,2R)-trans-2(3,4-difluorophenyl)cyclopropyl carboxamide 
• 1006614-49-8 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine 
• 1353964-60-9 trans-(1R,2R)-2-(3,4-difluorophenyl)-N-hydroxycyclopropanecarboxamide 
• 1353964-63-2 trans-(1R,2R)-N-(acetyloxy)-2-(3,4-difluorophenyl)cyclopropane carboxamide 
• 1353964-70-1 trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine (S)-ketopinate 
• 1353964-72-3 trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine (D)-camphorsulfonate 
• 1353964-85-8 trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine (R)-(-)-α-methoxyphenyl acetate 
• 2096989-55-6 [1S-[1a,2a,3β(1S*,2R*),5B]]-3-[7-[2-(3,4-difluorophenyl)cyclopropylamino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidine-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol 
• 1402222-66-5 trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine hydrochloride 
• 376608-71-8 trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt 

Relevant articles and documents

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

In this study a batch reactor process is compared to a flow chemistry approach for lipase-catalyzed resolution of the cyclopropanecarboxylate ester (±)-3. (1R,2R)-3 is a precursor of the amine (1R,2S)-2 which is a key building block of the API ticagrelor. For both flow and batch operation, the biocatalyst could be recycled several times, whereas in the case of the flow process the reaction time was significantly reduced.

Preparation method of phenyl-containing compound

The present invention discloses a method for preparing an phenyl-containing compound. The present invention provides a method for preparing a compound shown in formula I, comprising the following steps: in the presence of formamide or acetamide, in the pr

Preparation method of ticagrelor

The invention discloses a preparation method of ticagrelor. The preparation method comprises the following steps: (1) preparation of ticagrelor intermediate product 1-TK acid; (2) preparation of ticagrelor intermediate product 2-TK-amide; (3) preparation of ticagrelor intermediate product 3-TK-amino compound hydrochloride; (4) preparation of ticagrelor intermediate product 4-TK-amino compound R-tartrate; ( 5) preparation of ticagrelor intermediate product 5-TK-amino compound L-mandelate; and (6) preparation of ticagrelor-TK. The preparation method has the advantages of cost advantage, mature and stable process, stable product quality, and safe and reliable production process.