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1006378-90-0

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1006378-90-0 Usage

General Description

p38 MAPK-IN-1 is a chemical compound that is commonly used in research as a selective inhibitor of p38α MAP kinase. p38 MAPK-IN-1 has been found to effectively inhibit the phosphorylation and activation of p38α MAP kinase, which plays a key role in various cellular processes, including inflammation, apoptosis, and stress response. By targeting p38α MAP kinase, p38 MAPK-IN-1 has the potential to be utilized in the development of therapeutic treatments for diseases such as rheumatoid arthritis, inflammatory bowel disease, and cancer. Additionally, p38 MAPK-IN-1 has been extensively studied in preclinical research and has shown promising results in regulating cell proliferation, survival, and differentiation. Overall, p38 MAPK-IN-1 is a valuable tool for studying the role of p38α MAP kinase in cellular signaling pathways and could potentially lead to the development of novel drugs for various medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1006378-90-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,6,3,7 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1006378-90:
(9*1)+(8*0)+(7*0)+(6*6)+(5*3)+(4*7)+(3*8)+(2*9)+(1*0)=130
130 % 10 = 0
So 1006378-90-0 is a valid CAS Registry Number.

1006378-90-0Downstream Products

1006378-90-0Relevant articles and documents

1,7-naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase

Lumeras, Wenceslao,Vidal, Laura,Vidal, Bernat,Balagué, Cristina,Orellana, Adelina,Maldonado, M?nica,Dom?nguez, Mar?a,Segarra, V?ctor,Caturla, Francisco

experimental part, p. 7899 - 7910 (2012/01/05)

The design, synthesis, and ability to inhibit p38 MAP kinase by a novel series of naphthyridine N-oxides will be described. Some of these compounds showed a significant reduction in the LPS-induced TNF production in human whole blood. Structure-activity relationship studies revealed that N-oxide oxygen was essential for activity and was probably a determinant factor for its marked selectivity against other related kinases. After an extensive SAR exercise, several compounds from this series were identified as very potent p38 inhibitors. In vivo efficacy of some derivatives was demonstrated to reduce TNF levels in an acute murine model of inflammation (ED50 = 0.5 mg/kg in LPS-induced TNF production when dosed orally 1.5 h prior to LPS administration). The oral efficacy was further demonstrated in a chronic model of adjuvant arthritis in rats with established disease when administered orally (ED 50 1 mg/kg).

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