100648-13-3 Usage
Uses
Triclabendazole Sulfoxide is a metabolite of Triclabendazole (T774175), the only anthelmintic drug, which is active against immature, mature and adult stages of fluke.
Check Digit Verification of cas no
The CAS Registry Mumber 100648-13-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,6,4 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 100648-13:
(8*1)+(7*0)+(6*0)+(5*6)+(4*4)+(3*8)+(2*1)+(1*3)=83
83 % 10 = 3
So 100648-13-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H9Cl3N2O2S/c1-22(20)14-18-9-5-8(16)12(6-10(9)19-14)21-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)
100648-13-3Relevant articles and documents
2H-Benzimidazoles (Isobenzimidazoles). Part 7. A New Route to Triclabendazole and Congeneric Benzimidazoles
Iddon, Brian,Kutschy, Peter,Robinson, Andrew G.,Suschitzky, Hans,Kramer, Walter,Neugebauer, Franz A.
, p. 3129 - 3134 (2007/10/02)
A new synthesis of the selective anthelmintic agent triclabendazole 7 from the readily available 5,6-dichloro-2H-benzimidazole-2-spirocyclohexane 2 by simple steps is described.Analogous benzimidazoles difficult to prepare by conventional methods are similarly obtained.Triclabendazole can exist as a low-melting metastable solid (m.p. 85-90 deg C) convertible by heating or recrystallisation from ethanol into its stable form (m.p. 176-178 deg C).
