1006585-19-8Relevant articles and documents
Scalable synthesis of the VEGF-R2 kinase inhibitor JNJ-17029259 using ultrasound-mediated addition of MeLi-CeCl3 to a nitrile
Reuman, Michael,Beish, Sandra,Davis, Jeremy,Batchelor, Mark J.,Hutchings, Martin C.,Moffat, David F. C.,Connolly, Peter J.,Russell, Ronald K.
, p. 1121 - 1123 (2008/09/18)
(Chemical Equation Presented) The preparation of the selective VEGF-R2 kinase inhibitor 10 (JNJ-17029259) is described in which the key precursor, 4-(5-isoxazolyl)benzonitrile, undergoes clean transformation to the corresponding cumylamine derivative with