1006587-33-2

Basic information

• Product Name: 1-{(2S)-2-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)]ethyl}-4-{(2S)-2-[(tert-butoxycarbonyl)amino]-2-(methoxycarbonyl)ethyl}-benzene
• Synonyms: 1-{(2S)-2-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)]ethyl}-4-{(2S)-2-[(tert-butoxycarbonyl)amino]-2-(methoxycarbonyl)ethyl}-benzene
• CAS NO: 1006587-33-2
• Molecular Weight: 556.656
• Mol File: 1006587-33-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-{(2S)-2-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)]ethyl}-4-{(2S)-2-[(tert-butoxycarbonyl)amino]-2-(methoxycarbonyl)ethyl}-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{(2S)-2-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)]ethyl}-4-{(2S)-2-[(tert-butoxycarbonyl)amino]-2-(methoxycarbonyl)ethyl}-benzene(1006587-33-2)
• EPA Substance Registry System: 1-{(2S)-2-[(benzyloxycarbonyl)amino]-2-[(tert-butoxycarbonyl)]ethyl}-4-{(2S)-2-[(tert-butoxycarbonyl)amino]-2-(methoxycarbonyl)ethyl}-benzene(1006587-33-2)

Safety Data

• Hazardous Substances Data: 1006587-33-2(Hazardous Substances Data)

Upstream product

• 190579-73-8 2-benzyloxycarbonylamino-3-iodo-propionic acid tert-butyl ester 
• 266306-18-7 (S)-3-(4-Bromo-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester 

Relevant articles and documents

Negishi cross-coupling reactions of α-amino acid-derived organozinc reagents and aromatic bromides

The Negishi cross-coupling reaction of organozinc iodides derived from α-amino acids with aromatic bromides to give substituted phenylalanine derivatives is described, using either Pd(OAc)2 or Pd2(dba)3 in combination with P(o-Tol)3 as catalyst in DMF at 50 °C. Similar results are obtained using Pd[PtBu3]2 as catalyst. The difference in reactivity displayed between aryl iodides and bromides (ArI>ArBr) has been utilised in a short synthesis of an unsymmetrical, orthogonally protected para-phenylene bis-alanine derivative.