10066-14-5Relevant articles and documents
Novel anti-infection agents: Small-molecule inhibitors of bacterial transcription factors
Bowser, Todd E.,Bartlett, Victoria J.,Grier, Mark C.,Verma, Atul K.,Warchol, Taduesz,Levy, Stuart B.,Alekshun, Michael N.
, p. 5652 - 5655 (2008/02/13)
Structure-based drug design was utilized to identify potent small-molecule inhibitors of proteins within the AraC family of bacterial transcription factors, which control virulence in medically important microbes. These agents represent a novel approach to fight infectious disease and may be less likely to promote resistance development. These compounds lack intrinsic antibacterial activity in vitro and were able to limit a bacterial infection in a mouse model of urinary tract infection.
