10066-14-5Relevant academic research and scientific papers
Novel anti-infection agents: Small-molecule inhibitors of bacterial transcription factors
Bowser, Todd E.,Bartlett, Victoria J.,Grier, Mark C.,Verma, Atul K.,Warchol, Taduesz,Levy, Stuart B.,Alekshun, Michael N.
, p. 5652 - 5655 (2008/02/13)
Structure-based drug design was utilized to identify potent small-molecule inhibitors of proteins within the AraC family of bacterial transcription factors, which control virulence in medically important microbes. These agents represent a novel approach to fight infectious disease and may be less likely to promote resistance development. These compounds lack intrinsic antibacterial activity in vitro and were able to limit a bacterial infection in a mouse model of urinary tract infection.
Transcription factor modulating compounds and methods of use thereof
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Page/Page column 371, (2008/06/13)
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
