1006608-45-2Relevant academic research and scientific papers
Concise total synthesis of cruentaren A
Fuerstner, Alois,Bindl, Martin,Jean, Ludovic
, p. 9275 - 9278 (2007)
Converging on the target: The highly cytotoxic F-ATPase inhibitor cruentaren A constitutes an interesting lead in the quest for innovative chemotherapeutic agents for the treatment of various diseases, including cancer. Its synthesis was achieved in an overall yield of 3% by an expeditious convergent route involving a ring-closing aikyne metathesis reaction (RCAM) for the formation of the macrocyclic ring (see picture). (Chemical Equation Presented)
Preparation, modification, and evaluation of cruentaren a and analogues
Bindl, Martin,Jean, Ludovic,Herrmann, Jennifer,Mueller, Rolf,Fuerstner, Alois
supporting information; experimental part, p. 12310 - 12319 (2010/05/02)
An expeditious total synthesis of the highly cytotoxic F-ATPase inhibitor cruentaren A. (1) is described based on a. ring-closing alkyne metathesis (RCAM) reaction for the formation of the macrocylic ring. Other key transformations comprise a. C-acylation
