1006610-11-2Relevant academic research and scientific papers
Facile synthesis of a "ready to use" precursor of porphobilinogen and its amino acid derivatives
Soldermann, Carole Pissot,Vallinayagam, Ramakrishnan,Tzouros, Manuel,Neier, Reinhard
, p. 764 - 767 (2008)
(Chemical Equation Presented) A practical synthesis of porphobilinogen based on the biosynthetic mechanism is described. The crossed Mukayiama aldol reaction is the key step creating the central carbon-carbon bond between the two protected forms of 5-aminolevulinic acids. The optimized sequence gives a crystalline, storable precursor, which can be transformed in high yield into porphobilinogen and bioconjugates thereof. The enzymatic hydrolysis of the precursor produces porphobilinogen in quantitative yield.
