1006613-12-2Relevant articles and documents
Total synthesis and stereochemical reassignment of (+)-neopeltolide
Youngsaye, Willmen,Lowe, Jason T.,Pohlki, Frauke,Ralifo, Paul,Panek, James S.
, p. 9211 - 9214 (2008/12/22)
(Chemical Equation Presented) Take a closer look! The first enantioselective total synthesis, stereochemical reassignment, and absolute configuration of the metabolite neopeltolide is described (see picture). Synthetic highlights of this route include a modified Evans-Tishchenko reduction to introduce the C11 stereocenter, [4+2] annulation to construct the pyran system, and a Still-Gennari olefination to install the oxazole side chain.