1006614-08-9Relevant academic research and scientific papers
Atropisomeric lactam chemistry: catalytic enantioselective synthesis, application to asymmetric enolate chemistry and synthesis of key intermediates for NET inhibitors
Takahashi, Masashi,Tanabe, Hajime,Nakamura, Tsuyoshi,Kuribara, Daisuke,Yamazaki, Toshiyuki,Kitagawa, Osamu
, p. 288 - 296 (2010)
In the presence of (R)-SEGPHOS-Pd(OAc)2 catalyst, the intramolecular N-arylation of ortho-tert-butyl-NH-anilides possessing an iodophenyl group proceeded in a highly enantioselective manner (89-98% ee) to give optically active atropisomeric lac
Catalytic enantioselective synthesis of key intermediates for NET inhibitors using atropisomeric lactam chemistry
Kitagawa, Osamu,Kurihara, Daisuke,Tanabe, Hajime,Shibuya, Taichi,Taguchi, Takeo
, p. 471 - 474 (2008/09/17)
An atropisomeric lactam which was prepared with high enantioselectivity by catalytic asymmetric intramolecular N-arylation, was efficiently converted to synthetic intermediates for NET inhibitors through highly diastereoselective α-alkylation followed by
