1006693-79-3Relevant academic research and scientific papers
A stereoselective intramolecular cyclopropanation via a de novo class of push-pull carbenes derived from DMDO-epoxidations of chiral ynamides
Li, Hongyan,Antoline, Jennifer E.,Yang, Jin-Haek,Al-Rashid, Ziyad F.,Hsung, Richard P.
experimental part, p. 1309 - 1316 (2010/09/17)
This work describes the first examples of diastereoselective intramolecular cyclopropanations of a de novo class of push-pull carbenes derived from DMDO-epoxidations of chiral ynamides. This reaction sequence essentially constitutes a tandem epoxidation-cyclopropanation that effectively gives rise to a series of structurally unique amido-cyclopropanes. A plausible mechanistic model is proposed revealing insights into this novel cyclopropanation process.
Reactive intermediates from DMDO oxidation of ynamides. Trapping of a de novo chiral push-pull carbene via cyclopropanation
Al-Rashid, Ziyad F.,Hsung, Richard P.
, p. 661 - 663 (2008/09/17)
The reaction profile of DMDO oxidations of ynamides is described. This work illustrates the first examples of highly diastereoseiective intramolecular cyclopropanations of a push-pull carbene derived from alkyne oxidation. In addition, the ynamide oxidati
