1006725-76-3Relevant academic research and scientific papers
Synthesis of epi-oxetin via a serine-derived 2-methyleneoxetane
Blauvelt, Marisa L.,Howell, Amy R.
, p. 517 - 521 (2008/09/17)
(Chemical Equation Presented) The unique reactivity of 2-methyleneoxetanes and 1,5-dioxaspiro[3.2]hexanes has been exploited for the synthesis of epi-oxetin (26), an oxetane-containing β-amino acid. While the preparation of the natural product oxetin (1) was the original goal, the unexpected diastereoselectivity of an precedented reduction provided the epi-oxetin framework. The methodology described herein should be amenable for the preparation of oxetin with a change in nitrogen protection.
