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100678-32-8

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100678-32-8 Usage

Uses

Different sources of media describe the Uses of 100678-32-8 differently. You can refer to the following data:
1. Cardiac depressant (anti-arrhythmic).
2. Cibenzoline Succinate acts as a highly active class I antiarrhythmic agent.

General Description

Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(?) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient.

Biochem/physiol Actions

Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.

Check Digit Verification of cas no

The CAS Registry Mumber 100678-32-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,6,7 and 8 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 100678-32:
(8*1)+(7*0)+(6*0)+(5*6)+(4*7)+(3*8)+(2*3)+(1*2)=98
98 % 10 = 8
So 100678-32-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8)

100678-32-8 Well-known Company Product Price

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  • Sigma

  • (C1618)  Cibenzolinesuccinate  ≥97% (NMR), solid

  • 100678-32-8

  • C1618-10MG

  • 1,574.82CNY

  • Detail
  • Sigma

  • (C1618)  Cibenzolinesuccinate  ≥97% (NMR), solid

  • 100678-32-8

  • C1618-50MG

  • 6,288.75CNY

  • Detail

100678-32-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Cibenzoline succinate

1.2 Other means of identification

Product number -
Other names Cinobezile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100678-32-8 SDS

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