10068-54-9

Upstream product

• 1142-20-7 N-Cbz-Ala 
• 80919-02-4 C₂₃H₂₂NO₅P 
• 30134-68-0 1-Carbobenzoxy-3-methylaziridinon 

Downstream Products

• 42166-73-4 (S)-benzyl (1-oxo-1-(phenylamino)propan-2-yl)carbamate 
• 93806-91-8 N-carbobenzoxy-L-alanine 2,4-dinitrophenyl ester 
• 118143-72-9 (S)-2-Benzyloxycarbonylamino-propionic acid phenoxathiin-1-yl ester 
• 135958-55-3 (S)-2-Benzyloxycarbonylamino-propionic acid 10-oxo-10H-10λ⁴-phenoxathiin-1-yl ester 
• 114208-45-6 Z-Ala-Phe-O-DBF-S-S-(Boc)-Cys-OMaq 
• 313507-65-2 7-(N-carbobenzyloxy-L-alanyloxy)-5-hydroxy-2-phenylchromen-4-one 

Relevant academic research and scientific papers

Carboxylic sulfonic mixed anhydrides: General utility and application to the synthesis of ceftazidime

A high-yielding acylation process which utilizes a mixed anhydride of the type RCO2SO2CH3 for the synthesis of the cephalosporin ceftazidime is detailed. The mixed anhydride is conveniently prepared by addition of methanesulfonyl chloride to the triethylammonium salt of the acid 2a. Although known for some time, these anhydrides have not been used often in acylations. This lack of general utility is explained by side reactions, especially formation of the carboxylic symmetric anhydride in sterically unhindered systems.

Synthesis of amino-acid derivatives of chrysin

Various conjugates of amino acids with chrysin in which the amino acid was bonded through the C- or N-terminus to the flavone were prepared using peptide chemistry methods (symmetric anhydrides and activated esters).

PHASE MANAGED ORGANIC SYNTHESIS 3. SYMMETRICAL ANHYDRIDES FROM CARBOXYLIC ACIDS VIA POLYMER ASSISTED REACTION.

Symmetrical anhydrides are produced quickly and in high yield by treating mixtures of a carboxylic acid and one-half equivalent thionyl chloride in dichloromethane with a solid-state copolymer of 4-vinylpyridine.This conversion is accomplished equally well in batch or column mode.

A KINETIC STUDY OF PHOSPHINIC CARBOXYLIC MIXED ANHYDRIDES

Using 32.4 MHz (31)P n.m.r. spectroscopy, disproportionation of a series of phosphinic carboxylic mixed anhydrides derived from protected α-amino acids has been studied both as a function of the substituents at phosphorus and structure of the α-amino acid being activated.It was found that the rates of disproportionation were insignificant from a preparative aspect compared with aminolysis at 0 deg C.