100683-67-8Relevant academic research and scientific papers
Arylsulfonyloxy purine intermediates
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, (2008/06/13)
Compounds of the formula STR1 and the pharmaceutically acceptable salts thereof are disclosed. In these compounds, R1 is halogen, --SR4 wherein R4 is H or alkyl of 1 to 4 carbon atoms, --OCH3, --OSO2 Ar wherein Ar is phenyl or alkyl substituted phenyl wherein the alkyl group has 1 to 6 carbon atoms, --NR4 R5 wherein R4 is as defined above and R5 is H, alkyl of 1 to 4 carbon atoms, amino, alkanoyl of 1 to 8 carbon atoms, benzoyl, methoxy or hydroxy or R1 is --N(CH3)3+ X- wherein X is halogen or --OSO2 Ar wherein Ar is phenyl or alkyl substituted phenyl wherein the alkyl group has 1 to 6 carbon atoms; R2 is H, alkanoyl of 1 to 8 carbon atoms or benzoyl; R3 is A or B wherein A is STR2 and B is STR3 wherein R6 and R7 are independently selected from H and STR4 wherein R8 and R9 are independently selected from pharmaceutically acceptable cations and H, or R6 and R7 taken together are STR5 wherein R10 is selected from pharmaceutically acceptable cations and H; with the proviso that R4 is not H when: R5 is H, R3 is A, and R6 and R7 are H. The compounds have anti-viral activity.
Synthesis and Antiherpes Virus Activity of Phosphate and Phosphonate Derivatives of 9-guanine
Prisbe, Ernest J.,Martin, John C.,McGee, Danny P. C.,Barker, Molly F.,Smee, Donald F.,et al.
, p. 671 - 675 (2007/10/02)
A series of phosphate esters of 9-guanine (DHPG, 1) were synthesized and evaluated for antiherpes virus activity.The cyclic phosphate esters were made by a new, efficient method utilizing stannic chloride as a solubilizing
