1006867-21-5Relevant articles and documents
Development of CXCR3 antagonists. Part 3: Tropenyl and homotropenyl-piperidine urea derivatives
Watson, Robert J.,Allen, Daniel R.,Birch, Helen L.,Chapman, Gayle A.,Galvin, Frances C.,Jopling, Louise A.,Knight, Roland L.,Meier, Dorica,Oliver, Kathryn,Meissner, Johannes W.G.,Owen, David A.,Thomas, Elizabeth J.,Tremayne, Neil,Williams, Sophie C.
, p. 147 - 151 (2008/09/17)
The optimization of a series of 1-aryl-3-piperidinyl urea derivatives is described in which incorporation of tropenyl and homotropenyl moieties has led to significant improvements in activity and drug-like properties. Replacement of the central piperidine