1006876-28-3

Basic information

• Product Name: N-ethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide
• Synonyms: N-ethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide;2-(EthylcarbaMoyl)pyridine-5-boronic acid pinacol ester, 96%
• CAS NO: 1006876-28-3
• Molecular Formula: C₁₄H₂₁BN₂O₃
• Molecular Weight: 276.13914
• Mol File: 1006876-28-3.mol

Chemical Properties

• Melting Point: 52-54℃
• Boiling Point: 438.9±30.0 °C(Predicted)
• Appearance: /
• Density: 1.09±0.1 g/cm3(Predicted)
• PKA: 14.26±0.46(Predicted)
• CAS DataBase Reference: N-ethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-ethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide(1006876-28-3)
• EPA Substance Registry System: N-ethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide(1006876-28-3)

Safety Data

• Hazardous Substances Data: 1006876-28-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
N-ethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide is used as a building block in organic synthesis for the development of various pharmaceutical and agrochemical products. Its unique chemical structure allows it to form stable complexes with diols and polyols, making it a valuable tool in the synthesis of new compounds.
Used in Drug Development:
N-ethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide is studied for its potential use in the treatment of various diseases, including diabetes and cancer. Its ability to form stable complexes with biological molecules makes it a promising candidate for the development of new drugs with improved efficacy and safety profiles.
Used in Lab Research:
Due to its relative safety and non-toxicity, N-ethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide is suitable for use in laboratory research. Researchers can utilize N-ethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide to explore its chemical properties, reactivity, and potential applications in various fields, such as materials science and medicinal chemistry.
Used in Chemical Manufacturing:
N-ethyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)picolinaMide is considered a valuable compound in chemical manufacturing due to its potential applications in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. Its stable nature and compatibility with various chemical processes make it an attractive option for industrial-scale synthesis and production.

Upstream product

• 845305-88-6 5-bromo-pyridine-2-carboxylic acid ethylamide 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1093751-44-0 5-{3-chloro-4-[(5S)-2-(cis-4-hydroxycyclohexyl)-1-oxo-2,7-diazaspiro[4.5]dec-7-yl]phenyl}-N-ethylpyridine-2-carboxamide 

Relevant articles and documents

HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE

This invention relates to novel compounds and pharmaceutical compositions comprising. Compounds of the invention useful as modulators of Rho-associated protein kinase (ROCK), for example ROCK1 and/or ROCK2 inhibitors. Methods of treatment employing the compounds are also contemplated by the present invention. The compounds of the invention are useful in treating ROCK mediated diseases.

OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE

The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein R1 represents a carbamoyl group; R2 represents a lower alkyl group; both of X1 and X2 represent CH, or any one of X1 and X2 represents a nitrogen atom and the other represents CH; a group of represents a group selected from the group consisting of a pyridinyl, a pyrazinyl, a pyrazolyl, a thiadiazolyl, a triazolyl, an isoxazolyl and a thiazolyl group; and k is zero or 1, or relates to pharmaceutically acceptable salts thereof.

AZETIDINYL G-PROTEIN COUPLED RECEPTOR AGONISTS

Compounds of formula (I): or pharmaceutically acceptable salts thereof, are agonists of GPR119 and are useful for the treatment of diabetes and as peripheral regulators of satiety, e.g. for the treatment of obesity and metabolic syndrome.

SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1

The present invention relates to certain spirocyclic compounds that are inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 (11βHSD1), compositions containing the same, and methods of using the same for the treatment of diabetes, obesity and other di