1006877-03-7Relevant academic research and scientific papers
Paracyclophanes in action: Asymmetric catalytic dialkylzinc addition to imines using [2.2]paracyclophane-based N,O-ligands as catalysts
Dahmen, Stefan,Braese, Stefan
experimental part, p. 139 - 142 (2012/06/04)
The asymmetric addition of dibutylzinc to imines is achieved by employing [2.2]paracyclophane-based ketimine ligands with good to excellent enantioselectivities. A comparison to other organozinc reagent is made. Copyright
Catalytic enantioselective addition of organometallic reagents to N-formylimines using monodentate phosphoramidite ligands
Pizzuti, Maria Gabriella,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 940 - 947 (2008/09/18)
(Chemical Equation Presented) The asymmetric synthesis of protected amines via the copper/phosphoramidite-catalyzed addition of organozinc and organoaluminum reagents to N-acylimines, generated in situ from aromatic and aliphatic α-amidosulfones, is reported. High yields of optically active N-formyl-protected amines and enantioselectivities up to 99% were obtained. Under the reaction conditions, partial oxidation of the phosphoramidite ligand to the corresponding phosphoric amide was detected. A preliminary study on the origin and the effect on the catalytic addition reaction is presented.
