1006891-33-3

Usage

Uses

Used in Pharmaceutical Industry:
CIS-3-BOC-AMINO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID is used as a key building block for the synthesis of various pharmaceuticals. Its protected amine group and carboxylic acid functionality allow for versatile chemical reactions, facilitating the creation of diverse drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, CIS-3-BOC-AMINO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID serves as an intermediate in the development of agrochemicals. Its structural features and reactivity are harnessed to produce compounds that can be used in crop protection and other agricultural applications.
Used in Biochemical Research:
CIS-3-BOC-AMINO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID is utilized as a valuable tool in biochemical research for the modification of biomolecules. Its stability and reactivity make it suitable for exploring the interactions and modifications of biologically relevant molecules, contributing to advancements in understanding biological systems and the development of new therapeutic strategies.

Upstream product

• 1343915-25-2 4-(2,2-diethoxyethoxy)but-1-ene 
• 1220327-06-9 2-(but-3-en-1-yloxy)-N-hydroxyethanimine 
• 1220327-09-2 3,3a,4,5-tetrahydro-7H-pyrano[3,4-c][1,2]oxazole 
• 1363404-85-6 ethyl (3S,4R)-3-((tert-butoxycarbonyl)amino)tetrahydro-2H-pyran-4-carboxylate 
• 388109-30-6 ethyl (3S,4R)-3-(((1R)-1-phenylethyl)amino)tetrahydro-2H-pyran-4-carboxylate 
• 324767-92-2 ethyl 5-hydroxy-3,6-dihydro-2H-pyran-4-carboxylate 

Downstream Products

• 1350734-62-1 tert-butyl ((3S,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate 

Relevant academic research and scientific papers

Tetrahydropyran carboxylic acid derivative and synthesis method thereof

The invention belongs to the technical field of organic synthesis, and relates to (3S,4S)-3-(((9H-fluorene-9-yl)methoxy)carbonyl)-tetrahydro-2H-pyran-4-carboxylic acid and a synthesis method thereof.The provided synthetic method comprises the following steps: taking 3-butene-1-ol and 2-bromo-1,1-diethoxyethane as raw materials, and carrying out nine steps: substitution, substitution, cyclization,catalytic hydrogenation, Boc feeding, oxidation, chiral resolution, Boc removal and substitution reaction to prepare (3S, 4S)-3-((((9H-fluorene-9-yl) methoxy) carbonyl)-tetrahydro-2H-pyran-4-carboxylic acid. The synthetic route is simple, the cost is low, the efficiency is high, and the synthesized product can be used as a new medical intermediate.

Chemical synthesis method of 3-N-BOC-amino tetrahydro-2H-pyran-4-formate

The invention belongs to the field of chemical synthesis, and particularly relates to a chemical synthesis method of 3-N-BOC-amino tetrahydro-2H-pyran-4-formate. A synthesis route of the method is asfollows: (shown in the description). The chemical synthesis method adopts 3-butenol as a raw material to prepare 3-N-BOC-amino tetrahydro-2H-pyran-4-formate by virtue of six-step reaction. A high-efficiency synthesis method is provided for synthesis of the compound.

HETEROCYCLIC COMPOUND

The present invention provide a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of autoimmune diseases and/or inflammatory diseases, graft versus host disease, cancers, central nervous diseases including neurodegenerative diseases, Charcot-Marie-Tooth disease and the like, and a pharmaceutical composition comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors

β-Benzamido hydroxamic acids were discovered as potent TACE inhibitors. A computer model was constructed to help understanding the binding activities and guiding SAR study. SAR optimization led to the discovery of compound 30 which met all in vitro and in

Cyclic beta-amino acid derivatives as factor Xa inhibitors

The present application describes cyclic β-amino acid derivatives or pharmaceutically acceptable salt forms thereof, wherein the central core is a non-aromatic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.