10069-98-4

Basic information

• Product Name: N-Thiobenzoyl-L-alanin
• CAS NO: 10069-98-4
• Molecular Weight: 209.269
• Mol File: 10069-98-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Thiobenzoyl-L-alanin(CAS DataBase Reference)
• NIST Chemistry Reference: N-Thiobenzoyl-L-alanin(10069-98-4)
• EPA Substance Registry System: N-Thiobenzoyl-L-alanin(10069-98-4)

Safety Data

• Hazardous Substances Data: 10069-98-4(Hazardous Substances Data)

Upstream product

• 22962-97-6 4-methyl-2-phenylthiazolone 

Relevant articles and documents

Enzymatic Asymmetric Synthesis of α-Amino Acids. Enantioselective Cleavage of 4-Substituted Oxazolin-5-ones and Thiazolin-5-ones

A general enzymatic asymmetric synthesis of L-α-amino acids has been developed.This method entails the use of the Pseudomonas cepacia lipase (P-30) to catalyze the enantioselective methanolysis of a variety of 4-substituted 2-phenyloxazolin-5-one derivatives in a nonpolar organic solvent to furnish optically active N-benzoyl-L-α-amino acid methyl esters (ee = 66-98 percent), which in turn is subjected to a protease-catalyzed kinetic resolution yielding enantiomerically pure N-benzoyl-L-α-amino acids.This synergistic coupling of two enzymes allows the ready preparation of L-α-amino acids of high enantiopurity in yields greater than 50 percent, an inherent advantage over conventional resolution procedures.Two proteases were found to catalyze the enantioselective hydrolysis of a variety of 4-substituted 2-phenylthiazolin-5-one derivatives to give N-(thiobenzoyl)-L-α-amino acids of high optical purity.