100690-35-5

Usage

Uses

Used in Pharmaceutical Research:
HT-2 Toxin 3-Glucuronide is used as a research compound for studying the effects of trichothecene mycotoxins on DNA and cell death. Its role in inducing DNA damage and cell death makes it a valuable tool for understanding the mechanisms of action and potential therapeutic applications in various diseases.
Used in Toxicological Studies:
HT-2 Toxin 3-Glucuronide is utilized in toxicological research to investigate the toxic effects of trichothecene mycotoxins on living organisms. This helps in assessing the risks associated with exposure to these toxins and developing strategies for prevention and mitigation.
Used in Agricultural and Food Safety:
HT-2 Toxin 3-Glucuronide is employed in the development of detection methods and monitoring systems for trichothecene mycotoxins in agricultural products and food supplies. This ensures the safety and quality of food products, protecting consumers from potential health risks associated with mycotoxin contamination.

Upstream product

• 20181-53-7 T-2 toxin 
• 2616-64-0 uridine diphosphoglucuronic acid 
• 21259-20-1 T-2 toxin 
• 1245697-26-0 UDP-glucuronic acid 

Downstream Products

• 489-91-8 D-glucuronic acid 
• 26934-87-2 HT-2 toxin 

Relevant academic research and scientific papers

TRICHOTHECENE METABOLISM STUDIES. 2. STRUCTURE OF 3α-(1''β-D-GLUCOPYRANOSIDURONYL)-8α-ISOVALERYLOXY-SCIRPEN-3,4Β,15-TRIOL 15-ACETATE PRODUCED FROM T-2 TOXIN IN VITRO

The preparation and structure determination of the title compound is described.

HT-2 toxin 4-glucuronide as new T-2 toxin metabolite: Enzymatic synthesis, analysis, and species specific formation of T-2 and HT-2 toxin glucuronides by rat, mouse, pig, and human liver microsomes

Glucuronides of the mycotoxin T-2 toxin and its phase I metabolite HT-2 toxin are important phase II metabolites under in vivo and in vitro conditions. Since standard substances are essential for the direct quantitation of these glucuronides, a method for the enzymatic synthesis of T-2 and HT-2 toxin glucuronides employing liver microsomes was optimized. Structure elucidation by nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry revealed that besides T-2 toxin glucuronide and HT-2 toxin 3-glucuronide also the newly identified isomer HT-2 toxin 4-glucuronide was formed. Glucuronidation of T-2 and HT-2 toxin in liver microsomes of rat, mouse, pig, and human was compared and metabolites were analyzed directly by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). A distinct, species specific pattern of glucuronidation of T-2 and HT-2 toxin was observed with interesting interindividual differences. Until recently, glucuronides have frequently been analyzed indirectly by quantitation of the aglycone after enzymatic cleavage of the glucuronides by β-glucuronidase. Therefore, the hydrolysis efficiencies of T-2 and HT-2 toxin glucuronides using β-glucuronidases from Helix pomatia, bovine liver, and Escherichia coli were compared.