100693-60-5Relevant academic research and scientific papers
SYNTHESIS AND CONFIGURATIONAL STUDY OF 2,4-DISUBSTITUTED 1,3-DIPHENYLBUTANES AS POSSIBLE REARRANGEMENT PRODUCTS IN THE RING OPENING OF 2,3-DIBENZYLOXIRANES AND IN THE ELECTROPHILIC ADDITION TO THE CORRESPONDING OLEFINS
Crotti, Paolo,Macchia, Franco,Stoppioni, Annalisa
, p. 269 - 274 (2007/10/02)
Diols 4 and 5, and methoxy alcohols 6 and 7 were prepared as possible secondary 1,3-addition products in the acid-catalyzed ring opening reactions of cis-1, and trans-2,3-dibenzyloxirane, 2, and their relative configuration was determined through the 1H-NMR data of their precursors, i.e. the hydroxy esters 16 (for 4 and 6) and 17 (for 5 and 7) and on the basis of conformational considerations on each diastereomer.The chloromethoxy derivatives 12 and 13 were also prepared as representative 1,3-addition products in some electrophilic additions to the double bond of olefins cis-10 and trans-11 corresponding to epoxides 1 and 2, respectively.The configuration of 12 and 13 has been assigned on the basis of their method of preparation and confirmed through chemical correlations.
