100699-38-5Relevant academic research and scientific papers
Primary amine, thiourea-based dual catalysis motif for synthesis of stereogenic, all-carbon quaternary center-containing cycloalkanones
Kang, Jun Yong,Carter, Rich G.
supporting information; experimental part, p. 3178 - 3181 (2012/08/07)
The enantioselective synthesis of α,α-disubstituted cycloalkanones has been developed using a primary amine, thiourea-based dual catalysis pathway. A range of electrophiles and ring sizes are tolerated under the reaction conditions. A possible catalytic c
REGIOSELECTIVITY OF ENAMINE REACTIONS, PREFERENTIAL 2,2-DISUBSTITUTION OF 2-METHYLCYCLOHEXANONE IMINES
Hickmott, Peter W.,Rae, Bruce
, p. 2577 - 2580 (2007/10/02)
Secondary enamines, derived from imines of unsymmetrical α-substituted ketones, react with electrophilic alkenes at the more substituted position to give α,α-disubstituted ketones on hydrolysis.
