100704-41-4Relevant academic research and scientific papers
Reaction of amides with nitric oxide (NO)
Itoh, Takashi,Nagata, Kazuhiro,Matsuya, Yuji,Miyazaki, Michiko,Ohsawa, Akio
, p. 5017 - 5020 (1997)
Amides were allowed to react with nitric oxide in aprotic and non- ethereal solvents to give the corresponding N-nitroso derivatives. The reaction was accelerated by addition of oxygen. The solvent effect revealed that the reaction did not proceed in the presence of protic media.
Tert -Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions
Sureshbabu, Popuri,Azeez, Sadaf,Chaudhary, Priyanka,Kandasamy, Jeyakumar
supporting information, p. 845 - 850 (2019/01/30)
A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-butyl nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.
