1007091-60-2Relevant academic research and scientific papers
Multicomponent cyclocondensations of β-ketosulfones with aldehydes and aminoazole building blocks
Gladkov, Eugene S.,Chebanov, Valentin A.,Desenko, Sergey M.,Shishkin, Oleg V.,Shishkina, Svetlana V.,Dallinger, Doris,Kappe, C. Oliver
experimental part, p. 469 - 480 (2009/09/08)
The multicomponent reaction of methylsulfonylacetone (or α-methylsulfonylacetophenone) with aromatic aldehydes and aminoazoles (or urea) under microwave irradiation to yield 5,8-dihydroimidazolo[1,2-a]pyrimidines and 4,7-dihydro[1,2,4]triazolo[l,5-a]pyrimidines was studied. The influence of the type of aminoazole building block on the reactivity was established. In addition, an unusual reaction pathway for the Biginelli-type condensation of methylsulfonylacetone with aldehydes and urea leading to non-classical Hantzsch-type dihydropyridines was found.
