1007093-77-7

Usage

Uses

Used in Organic Synthesis:
(R)-3-(4-methyl-6-oxocyclohex-1-en-1-yl)propanenitrile is used as an intermediate in the synthesis of various organic compounds. Its unique structure, which includes a nitrile group and a cyclohexenone ring, allows for a range of chemical reactions and modifications, making it a valuable building block in the creation of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (R)-3-(4-methyl-6-oxocyclohex-1-en-1-yl)propanenitrile may be utilized as a starting material or a key intermediate for the development of new pharmaceuticals. Its structural features could be exploited to design and synthesize novel bioactive molecules with potential therapeutic applications.
Used in Pharmaceutical Industry:
(R)-3-(4-methyl-6-oxocyclohex-1-en-1-yl)propanenitrile is used as a precursor for the development of new drugs in the pharmaceutical industry. Its unique structural features and the presence of a chiral center make it an attractive candidate for the synthesis of enantiomerically pure compounds, which are often required for the desired biological activity and to avoid potential side effects associated with racemic mixtures.
Used in Chemical Research:
(R)-3-(4-methyl-6-oxocyclohex-1-en-1-yl)propanenitrile serves as a subject of study in chemical research, where its properties, reactivity, and potential applications are investigated. Understanding the behavior of (R)-3-(4-methyl-6-oxocyclohex-1-en-1-yl)propanenitrile can contribute to the advancement of organic chemistry and the discovery of new synthetic methods and applications.

Upstream product

• 915122-92-8 (R)-5-methyl-2-iodo-2-cyclohexen-1-one 
• 107-13-1 acrylonitrile 
• 88154-77-2 (5R)-5-methyl-2-(phenylsulfinyl)cyclohexan-1-one 
• 89-82-7 pulegone 
• 308358-04-5 (6R)-2,2,6-trimethyl-1-oxaspiro[2.5]octan-4-one 
• 101693-93-0 (5R)-5-methyl-2-(phenylthio)cyclohexan-1-one 

Downstream Products

• 1233010-08-6 dimethyl (R)-2-(2-((1S,5R)-3-[(1,1-dimethylethyl)dimethylsilyloxy]-2-(2-cyanoethyl)-5-methylcyclohex-2-enyl)acetyl)cyclopropane-1,1-dicarboxylate 
• 1233010-03-1 dimethyl (S)-2-(2-((1S,5R)-3-[(1,1-dimethylethyl)dimethylsilyloxy]-2-(2-cyanoethyl)-5-methylcyclohex-2-enyl)acetyl)cyclopropane-1,1-dicarboxylate 
• 34399-44-5 des-N-methyl-α-obscurine 

Relevant academic research and scientific papers

Bioinspired Diversification Approach Toward the Total Synthesis of Lycodine-Type Alkaloids

Nitrogen heterocycles (azacycles) are common structural motifs in numerous pharmaceuticals, agrochemicals, and natural products. Many powerful methods have been developed and continue to be advanced for the selective installation and modification of nitrogen heterocycles through C-H functionalization and C-C cleavage approaches, revealing new strategies for the synthesis of targets containing these structural entities. Here, we report the first total syntheses of the lycodine-type Lycopodium alkaloids casuarinine H, lycoplatyrine B, lycoplatyrine A, and lycopladine F as well as the total synthesis of 8,15-dihydrohuperzine A through bioinspired late-stage diversification of a readily accessible common precursor, N-desmethyl-β-obscurine. Key steps in the syntheses include oxidative C-C bond cleavage of a piperidine ring in the core structure of the obscurine intermediate and site-selective C-H borylation of a pyridine nucleus to enable cross-coupling reactions.

Enantiospecific formal total synthesis of (+)-fawcettimine

The diastereospecific attack of the silyl enol ether on the activated cyclopropyl diester 27 generated the hydrindanone 28 with complete stereocontrol. Thermal decarbomethoxylation of 28 gave the monoester 29, a key intermediate in Heathcocks synthesis, thereby completing a formal total synthesis of (+)-fawcettimine 1. The analogous cyclization of 33, the diastereomer of 27, afforded the diastereomeric diester 34, thereby demonstrating that the cyclization process is diastereospecific.

Intermolecular radical addition reactions of α-iodo cycloalkenones and a synthetic study of the formal synthesis of enantiopure fawcettimine

The generation of α-carbonyl vinyl radicals from α-iodo cycloalkenones, the scope of their participation in intermolecular addition reactions with electron-withdrawing olefins are studied and a synthetic study of the formal synthesis of enantiopure fawcet