1007098-93-2

Upstream product

• 1119204-83-9 3-chloro-6-(3,5-difluorophenyl)pyridazine 
• 156545-07-2 3,5-difluorophenylboronic acid 
• 123577-99-1 3′,5′-difluoroacetophenone 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 1007099-05-9 methyl 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoate 
• 1007098-68-1 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzonitrile 
• 1007096-69-6 6-(3,5-difluorophenyl)-2-[3-(5-methyl-1,2,4-oxadiazol-3-yl)benzyl]-2H-pyridazin-3-one 
• 1007097-54-2 6-(3,5-difluorophenyl)-2-[3-(2-methylthiazol-4-yl)benzyl]-2H-pyridazin-3-one 
• 1192224-51-3 2-(6-bromopyridin-2-ylmethyl)-6-(3,5-difluorophenyl)-2H-pyridazin-3-one 
• 1007098-98-7 2-(3-aminobenzyl)-6-(3,5-difluorophenyl)-2H-pyridazin-3-one 
• 1119204-85-1 6-(3,5-difluorophenyl)-2-(3-nitrobenzyl)-2H-pyridazin-3-one 
• 1007099-00-4 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoic acid 
• 1119204-84-0 3-(4-methylpiperazin-1-yl)propyl {3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}carbamate 
• 1119204-93-1 3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-N-prop-2-ynylbenzamide 
• 1119204-86-2 2,2,2-trichloro-N-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}acetamide 
• 1119204-80-6 6-(3,5-difluorophenyl)-2-[3-(5-methylthiazol-2-yl)-benzyl]-2H-pyridazine-3-thione 
• 1119204-95-3 tert-butyl 4-(3-{3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]benzoylamino}-2-hydroxypropyl)piperidine-1-carboxylate 
• 1119204-87-3 3-chloropropyl {3-[3-(3,5-difluorophenyl)-6-oxo-6H-pyridazin-1-ylmethyl]phenyl}carbamate 

Relevant academic research and scientific papers

Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors

We report a series of phenyl substituted pyridazin-3-ones substituted with morpholino-pyrimidines. The SAR of the phenyl was explored and their c-Met kinase and cell-based inhibitory activity toward c-Met driven cell lines were evaluated. Described herein

6-THIOXOPYRIDAZINE DERIVATIVES

Compounds of the formula I, in which R1, R2 and R3 have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours.