1007120-36-6Relevant academic research and scientific papers
Copper- and phosphine-free Sonogashira coupling reaction catalyzed by polyurea-encapsulated palladium(II)
Kuang, Yun-Yan,Chen, Fen-Er
, p. 897 - 902 (2009)
A polyurea-encapsulated palladium catalyst (Pd EnCat 30) was first applied to Sonogashira cross-coupling reactions in the absence of a copper salt co-catalyst and under phosphine-free conditions. This polymer-anchored homogeneous palladium catalyst effici
A copper-free, cross-coupling of terminal alkynes with hetaryl halides
Arsenyan, Pavel,Rubina, Kira,Vasiljeva, Jelena,Belyakov, Sergey
, p. 6524 - 6528 (2013)
Substituted ethynyl heterocycles and heteroarylbutenynes are synthesized efficiently in good yields via a copper-free, cross-coupling reaction.
Synthesis of 4-Oxoisoxazoline N-Oxides via Pd-Catalyzed Cyclization of Propargylic Alcohols with tert-Butyl Nitrite
Feng, Kai-Wen,Ban, Yong-Liang,Yuan, Pan-Feng,Lei, Wen-Long,Liu, Qiang,Fang, Ran
supporting information, p. 3131 - 3135 (2019/05/10)
A cyclization of propargylic alcohols with tert-butyl nitrite at room temperature in air was achieved using Pd(OAc)2 as catalyst. The first reported 4-oxoisoxazoline N-oxides could be directly accessed from a range of multisubstituted propargylic alcohols in moderate to excellent yields under mild conditions. Density functional theory calculations indicated that the reaction proceeds through a palladium-catalyzed NO2 addition that efficiently generates a ketoxime radical, which eventually produces 4-oxoisoxazoline N-oxide.
Ethynyl-cyclohexanol: an efficient acetylene surrogate in Sonogashira coupling
Csékei, Márton,Novák, Zoltán,Kotschy, András
, p. 975 - 982 (2008/09/17)
The Sonogashira coupling of aryl halides in the presence of 1-ethynyl-cyclohexanol as an acetylene source provides an efficient method for the synthesis of diarylacetylenes without the isolation of the appropriate arylacetylenes.
