100714-43-0Relevant academic research and scientific papers
SYNTHESIS AND PROPERTIES OF 2-AMINO-4,6-DIMETHYLNICOTINIC ACID ARYLAMIDES
Demina, L. M.,Konshin, M. E.
, p. 1179 - 1181 (2007/10/02)
It is shown that on boiling 2-amino-4,6-dimethylnicotinic acid arylamides with triethyl orthoformate in acetic anhydride, derivatives of 3-aryl-5,7-dimethyl-4-oxo-3,4-dihydropyridopyrimidine are formed.The same compounds are obtained by ternary condensation of ethyl 2-amino-4,6-dimethylnicotinate with triethyl orthoformate and arylamines.On reaction with urea or ammonium thiocyanate, the ethyl ester or anilides of 2-amino-4,6-dimethylnicothinic acid are converted to 2,4-dioxo- or 4-oxo-2-thio-pyridopyrimidines respectively.
