100716-25-4

Basic information

• Product Name: 4-bromobenzyl 4-methylphenyl sulfide
• Synonyms: 4-bromobenzyl 4-methylphenyl sulfide
• CAS NO: 100716-25-4
• Molecular Formula: C₁₄H₁₃BrS
• Molecular Weight: 293.22202
• Mol File: 100716-25-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-bromobenzyl 4-methylphenyl sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromobenzyl 4-methylphenyl sulfide(100716-25-4)
• EPA Substance Registry System: 4-bromobenzyl 4-methylphenyl sulfide(100716-25-4)

Safety Data

• Hazardous Substances Data: 100716-25-4(Hazardous Substances Data)

Upstream product

• 106-45-6 para-thiocresol 
• 589-17-3 p-bromobenzyl chloride 
• 106-38-7 para-bromotoluene 
• 100716-17-4 1-bromo-4-((p-tolylsulfinyl)methyl)benzene 
• 10486-08-5 sodium p-thiocresolate 

Downstream Products

• 26885-97-2 1-bromo-4-(p-tolylsulfonylmethyl)benzene 
• 100716-17-4 1-bromo-4-((p-tolylsulfinyl)methyl)benzene 

Relevant articles and documents

Nickel-catalyzed oxidative dehydrogenative coupling of alkane with thiol for C(sp3)-S bond formation

A nickel-catalyzed oxidative dehydrogenative coupling reaction of alkane with thiol for the construction of C(sp3)-S bond has been established, affording more than 50 alkyl thioethers. Notably, pharmaceutical and agrochemicals, such as Provigil, Chlorbenside and Pyridaben, were readily synthesized by this approach. The sterically hindered ligand BC and disulfide which was formed in situ oxidation of thiol, efficiently avoiding nickel-catalyst poisoning. A set of mechanistic experiments disclose both Ni-catalyzed and Ni-free HAA processes.

Mild and efficient deoxygenation of sulfoxides to sulfides with triflic anhydride/potassium iodide reagent system

It was found that the combination of triflic anhydride/potassium iodide was an effective promoter for the deoxygenation of sulfoxides and gave the corresponding sulfides in excellent yield in acetonitrile at room temperature. It is worth mentioning that this reagent system is chemoselective and tolerates various functional groups, such as alkene, ketone, ester, aldehyde, acid, and oxime. Georg Thieme Verlag Stuttgart.