1007197-64-9Relevant academic research and scientific papers
A regioselective approach to trisubstituted 2 (or 6)-arylaminopyrimidine-5- carbaldehydes and their application in the synthesis of structurally and electronically unique G∧C base precursors
Beingessner, Rachel L.,Deng, Bo-Liang,Fanwick, Phillip E.,Fenniri, Hicham
, p. 931 - 939 (2008/09/18)
(Chemical Equation Presented) An efficient regioselective synthesis of trisubstituted 2(or 6)-arylaminopyrimidine-5-carbaldehydes has been developed via an SNAr reaction of 2,4,6-trichloropyrimidine-5-carbaldehyde with aniline, methylamine, and alkoxide nucleophiles using a combination of phase-transfer catalysis and more traditional SNAr reaction conditions. We demonstrate that in a few synthetic steps, highly functionalized fused-bicyclic pyrimidine substrates can be accessed from the trisubstituted 2-arylaminopyrimidine-5-carbaldehydes. Furthermore, these fused-bicyclic compounds are readily derivatized using the Suzuki cross-coupling reaction to generate electronically and structurally unique G∧C base precursors.
