1007218-99-6Relevant articles and documents
3-Aminopyrrolidines from α-aminoacids: Total synthesis of (+)-nemonapride from D-alanine
Cam, Thuy Hoang,Viet, Hoang Nguyen,Alezra, Valerie,Kouklovsky, Cyrille
, p. 1162 - 1164 (2008)
(Chemical Equation Presented) The antipsychotic compound nemonapride 1 was synthesized in nine steps from D-alanine 2. The key steps for the synthesis of the 3-aminopyrrolidine moiety include a Birch reduction of a cyclic enaminoester and the reduction of a pyrrolidinone to the pyrrolidine 7. Final coupling with the benzoic acid derivative 9 gave 1 as a single enantio- and diastereomer.