1007220-98-5Relevant academic research and scientific papers
Stereospecificity of retinol saturase: Absolute configuration, synthesis, and biological evaluation of dihydroretinoids
Moise, Alexander R.,Dominguez, Marta,Alvarez, Susana,Alvarez, Rosana,Schupp, Michael,Cristancho, Ana G.,Kiser, Philip D.,De Lera, Angel R.,Lazar, Mitchell A.,Palczewski, Krzysztof
, p. 1154 - 1155 (2008/10/09)
Retinol saturase carries out a stereospecific saturation of the C13-C14 double bond of all-trans-retinol to generate (13R)-all-trans-13,14-dihydroretinol. This compound is found in cells expressing mouse or zebrafish retinol saturase and in the livers of mice fed retinyl palmitate. All-trans-13,14-dihydroretinol is oxidized in vivo to all-trans-13,14-dihydroretinoic acid, a highly selective agonist of the retinoic acid receptor. The naturally occurring (13R)-all-trans-13,14-dihydroretinoic acid is a weaker agonist than the (13S) enantiomer, indicating enantioselective recognition by the ligand-binding pocket of this receptor. Consequently the (13S) enantiomer, acting through the retinoic acid receptor, also inhibits adipose differentiation more potently than the (13R) enantiomer. Copyright
COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISEASES
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Page/Page column 27, (2008/12/05)
A pharmaceutical composition for treating a metabolic disease in a mammalian subject includes a therapeutically effective amount of all-trans-13,14-dihydroretinoid, all-trans-13,14-dihydroretinoid derivative, or agent capable of modulating the level of at least one all-trans-13,14-dihydroretinoid or all-trans-13,14-dihydroretinoid derivative in the subject.
