1007229-72-2Relevant academic research and scientific papers
Synthetic studies on CP-225,917 and CP-263,114: Access to advanced tetracyclic systems by intramolecular conjugate displacement and [2,3]-wittig rearrangement
Malihi, Farzad,Clive, Derrick L. J.,Chang, Che-Chien,Minaruzzaman
, p. 996 - 1013 (2013/04/10)
An advanced intermediate related to the structures of CP-225,917 and CP-263,114 was constructed by a sequence based on the use of Grob-like fragmentation, intramolecular conjugate displacement, and [2,3]-Wittig rearrangement. A variant of the [2,3]-Wittig rearrangement was developed.
All-carbon intramolecular conjugate displacement reactions: An effective route to carbocycles
Prabhudas, Bodhuri,Clive, Derrick L. J.
, p. 9295 - 9297 (2008/12/22)
(Chemical Equation Presented) Working together: Synergy between Michael addition and SN2′ displacement allows stabilized carbanions or the nucleophilic carbon atoms of enamines to undergo intramolecular addition to an α,β-unsaturated ester unit bearing an allylic leaving group to generate unsaturated carbocycles (see scheme). The starting esters are available by a selenium-based alternative to the classical Baylis-Hillman reaction, and complex structures can be assembled.
