100727-36-4Relevant academic research and scientific papers
Ascorbic acid as an initiator for the direct C-H arylation of (hetero)arenes with anilines nitrosated in situ
Crisostomo, Fernando Pinacho,Martin, Tomas,Carrillo, Romen
supporting information, p. 2181 - 2185 (2014/03/21)
Ascorbic acid (vitaminC) has been used as a radical initiator in a metal-free direct C-H arylation of (hetero)arenes. Starting from an aniline, the corresponding arenediazonium ion is generated in situ and immediately reduced by vitaminC to an aryl radical that undergoes a homolytic aromatic substitution with a (hetero)arene. Notably, neither heating nor irradiation is required. This procedure is mild, operationally simple, and constitutes a greener approach to arylation. Copyright
Substituted biphenyl derivatives
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, (2008/06/13)
The invention relates to compounds of the formula I in which R1, R2, R3, R4 and X have the meaning indicated in the text. The compounds act as inhibitors of factors Xa and VIIa and can therefore be employed for
