100727-43-3

Upstream product

• 2063-19-6 4-bromo-2-methylbut-3-yn-2-ol 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 636-98-6 p-nitrobenzene iodide 
• 33432-53-0 2-methyl-4-(4-nitrophenyl)but-3-yn-2-ol 
• 940-13-6 1-(2-bromoethynyl)-4-nitrobenzene 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 5929-72-6 2,7-dimethyl-octa-3,5-diyne-2,7-diol 
• 763-12-2 2-methyl-3,5-hexadiyn-2-ol 

Downstream Products

• 7642-33-3 1-(buta-1,3-diyn-1-yl)-4-nitrobenzene 
• 169955-70-8 2,2-dimethyl-5-(4-nitrobenzyl)furan-3(2H)-one 
• 1342819-94-6 2,2-dimethyl-5-(4-nitrobenzoyl)furan-3(2H)-one 

Relevant academic research and scientific papers

1-Iodobuta-1,3-diynes in Copper-Catalyzed Azide-Alkyne Cycloaddition: A One-Step Route to 4-Ethynyl-5-iodo-1,2,3-triazoles

Cu-catalyzed 1,3-dipolar cycloaddition of iododiacetylenes with organic azides using iodotris(triphenylphosphine)copper(I) as a catalyst was found to be an efficient one-step synthetic route to 5-iodo-4-ethynyltriazoles. The reaction is tolerant to various functional groups in both butadiyne and azide moieties. The synthetic application of 5-iodo-4-ethynyl triazoles obtained was also evaluated: the Sonogashira coupling with alkynes resulted in unsymmetrically substituted triazole-fused enediyne systems, while the Suzuki reaction yielded the corresponding 5-aryl-4-ethynyl triazoles.

Glaser-Hay hetero-coupling in a bimetallic regime: A Ni(II)/Ag(i) assisted base, ligand and additive free route to selective unsymmetrical 1,3-diynes

A Ni(OAc)2/Ag(OTf) catalysed coupling of aryl alkynes and propargylic alcohol/ether/ester gave the corresponding unsymmetrical 1,3-diynes in good to excellent yields. The reaction does not require bases, ligands or additives and shows excellent hetero-selectivity, thereby addressing the current challenges in the field of coupling of two different terminal alkynes.

Copper Catalysis for Selective Heterocoupling of Terminal Alkynes

A Cu-catalyzed selective aerobic heterocoupling of terminal alkynes is disclosed, which enables the synthesis of a broad range of unsymmetrical 1,3-diynes in good to excellent yields. The results disprove the long-held belief that homocouplings are exclusively favored in the Glaser-Hay reaction.

Carbon dioxide-mediated synthesis of 3(2H)-furanones from diyne alcohols

A novel type of carbon dioxide-mediated reaction of diyne alcohols without any metal catalysts was reported. Carbon dioxide held the key to the success of this reaction, in which 3(2H)-furanones were selectively obtained in moderate to high yields.

Synthesis and molecular properties of donor-π-spacer-acceptor ynamides with up to four conjugated alkyne units

A set of push-pull ynamides with up to four conjugated triple bonds has been synthesized and the molecular properties of these new carbon rods have been characterised showing effective intramolecular charge transfers and high values for the change of the

Solid-state polymerization of monophenylbutadiyne derivatives

Solid-state polymerization of phenylbutadiyne derivatives with o-nitro, m-nitro or p-nitro group was investigated. All monomers in bulk crystals could be thermally polymerized to become black suggesting formation of extended pi-conjugation system. However, no regular polydiacetylene structures were confirmed by the structural analysis. Nanocrystals of the m-nitro derivative were prepared, and the different polymerization behavior compared with in the bulk crystals was observed. Copyright Taylor & Francis Group, LLC.