100728-09-4Relevant articles and documents
Novel phenazine substance, preparation method and application thereof
-
Paragraph 0062; 0063; 0064, (2017/08/28)
The invention discloses a novel phenazine substance, a preparation method and an application thereof. The novel phenazine substance is a compound represented as the general formula (1), or a medically acceptable salt thereof, or a hydrate of the medically acceptable salt thereof, wherein n is 0 or 1, X is -NHCO- or -CONH-; R is halogen or a hydroxyl group; R1, R2 and R3 are same or different and are independently represented as hydrogen, an amino group, a hydroxyl group, a methyl group, a methoxyl group or -COOCH3; R4, R5, R6 and R7 are same or different and are independently represented as hydrogen, an amino group, a hydroxyl group, a methyl group, a methoxyl group, -COOCH3, halogen, a carboxyl group, or a halogenated methyl group; wherein the general formula (1) excludes the following situation: when n is 1 and x is the -NHCO-, R2 is a hydroxyl group, and R1, R3, R4, R5, R6 and R7 are all hydrogen. The novel phenazine substance, compared with an anticancer medicine or other phenazine substances in the prior art, has higher anticancer activity, lower toxicity and higher selectivity.