1007346-11-3Relevant academic research and scientific papers
How to make five contiguous stereocenters in one reaction: Asymmetric organocatalytic synthesis of pentasubstituted cyclohexanes
Reyes, Efraim,Jiang, Hao,Milelli, Andrea,Elsner, Petteri,Hazell, Rita G.,Jorgensen, Karl Anker
, p. 9202 - 9205 (2007)
(Chemical Equation Presented) Give me five! An organocatalyzed two-component domino reaction has been developed in which two new C-C bonds and five stereocenters are created in a one-pot fashion (see scheme; DABCO = 1,4-diazabicyclo[2.2.2]octane, TMS = trimethylsilyl). The striking features of this transformation are the high preference for one diastereomer (out of 32 possible isomers) and enantioselectivities of up to 94 %.
