1007346-28-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-(2,3-difluoro-4-bromophenyl)ethanone is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique chemical structure contributes to the development of new compounds with potential therapeutic and pesticidal properties.
Used in Dye, Flavor, and Fragrance Industries:
DFBPE is utilized as an intermediate in the production of dyes, flavors, and fragrances. Its chemical versatility allows for the creation of a wide range of colorants, additives, and aromatic compounds used in various applications, from textiles to the food and perfume industries.

Upstream product

• 1007346-27-1 2-(4-bromo-2,3-difluorophenyl)-2-methyl[1,3]dioxolane 

Downstream Products

• 1007346-38-4 C₁₅H₁₀BrF₂N₃ 
• 1007346-35-1 C₁₅H₉BrF₃N₃ 

Relevant academic research and scientific papers

7-Fluoroindazoles as potent and selective inhibitors of factor Xa

We have developed a novel series of potent and selective factor Xa inhibitors that employ a key 7-fluoroindazolyl moiety. The 7-fluoro group on the indazole scaffold replaces the carbonyl group of an amide that is found in previously reported factor Xa inhibitors. The structure of a factor Xa cocrystal containing 7-fluoroindazole 51a showed the 7-fluoro atom hydrogen-bonding with the N-H of Gly216 (2.9 ?) in the peptide backbone. Thus, the 7-fluoroindazolyl moiety not only occupied the same space as the carbonyl group of an amide found in prior factor Xa inhibitors but also maintained a hydrogen bond interaction with the protein's β-sheet domain. The structure-activity relationship for this series was consistent with this finding, as the factor Xa inhibitory potencies were about 60-fold greater (ΔΔG ≈ 2.4 kcal/mol) for the 7-fluoroindazoles 25a and 25c versus the corresponding indazoles 25b and 25d. Highly convergent synthesis of these factor Xa inhibitors is also described.