1007351-68-9Relevant academic research and scientific papers
High throughput synthesis of diverse 2,5-disubstituted indoles using titanium carbenoids bearing boronate functionality
Main, Calver A.,Petersson, Hanna M.,Rahman, Shahzad S.,Hartley, Richard C.
, p. 901 - 914 (2008/09/16)
A titanium benzylidene complex bearing a boronate group converted resin-bound esters into enol ethers. Suzuki cross-coupling with aryl iodides followed by cleavage with acid completed the solid-phase synthesis of 2,5-disubstituted N-Boc-indoles. Also reported is the use of tert-butyllithium and 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane to convert an aryl bromide into an arylboronate in the presence of a dithiane, with simultaneous reduction of an aryl azide to an amine.
