1007377-58-3Relevant academic research and scientific papers
An improved and scalable synthesis of N-(5-(4-cyanophenyl)-3-hydroxypicolinoyl)glycine, a promising PHD2 inhibitor for the treatment of anemia
Lei, Yonghua,Hu, Tianhan,Hu, Mingyang,Yang, Li,Wu, Yue,Xiang, Hua,Zhang, Lianshan,Shen, Lingjia,You, Qidong,Zhang, Xiaojin
, p. 5017 - 5019 (2015/08/06)
Abstract An improved and scalable synthetic method of N-(5-(4-cyanophenyl)-3-hydroxypicolinoyl)glycine, a promising inhibitor of PHD2, is described. The optimized route staring from commercially available 5-bromo-3-nitropicolinonitrile takes only five chemical steps and has a dramatically increased total yield of 37.6% without chromatographic purifications.
