1007390-35-3Relevant academic research and scientific papers
Nucleophilic asymmetric epoxidation catalyzed by cyclic guanidines
Kita, Tetsuya,Shin, Bongki,Hashimoto, Yuichi,Nagasawa, Kazuo
scheme or table, p. 241 - 247 (2009/09/06)
Asymmetric nucleophilic epoxidation of chalcone and its derivatives was studied using chiral cyclic guanidine compounds. Pentacyclic guanidine 1a, which has a characteristic closed-type cavity, catalyzed the reaction to give epoxides with 39-60% ee.The newly developed tricyclic guanidine 4 drastically accelerated the reaction, and induced the asymmetric induction of chalcones with almost the same level of 1a.
