Cas 1007396-25-9,dimethyl 4-((1-(tert-butoxycarbonyl)-1H-indol-3-yl)methyl)pyridazine-3,6-dicarboxylate

1007396-25-9

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Basic information

Product Name: dimethyl 4-((1-(tert-butoxycarbonyl)-1H-indol-3-yl)methyl)pyridazine-3,6-dicarboxylate
Synonyms: dimethyl 4-((1-(tert-butoxycarbonyl)-1H-indol-3-yl)methyl)pyridazine-3,6-dicarboxylate
CAS NO:1007396-25-9
Molecular Formula:
Molecular Weight: 425.441
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: dimethyl 4-((1-(tert-butoxycarbonyl)-1H-indol-3-yl)methyl)pyridazine-3,6-dicarboxylate(CAS DataBase Reference)
NIST Chemistry Reference: dimethyl 4-((1-(tert-butoxycarbonyl)-1H-indol-3-yl)methyl)pyridazine-3,6-dicarboxylate(1007396-25-9)
EPA Substance Registry System: dimethyl 4-((1-(tert-butoxycarbonyl)-1H-indol-3-yl)methyl)pyridazine-3,6-dicarboxylate(1007396-25-9)

Safety Data

Hazard Codes: N/A
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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
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Hazardous Substances Data: 1007396-25-9(Hazardous Substances Data)

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1007396-25-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1007396-25-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,7,3,9 and 6 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1007396-25:
(9*1)+(8*0)+(7*0)+(6*7)+(5*3)+(4*9)+(3*6)+(2*2)+(1*5)=129
129 % 10 = 9
So 1007396-25-9 is a valid CAS Registry Number.

1007396-25-9Upstream product

1007396-25-9Downstream Products

1007396-25-9Relevant academic research and scientific papers

UPP AMPHIPHILIC ALPHA-HELIX MIMETICS

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Page/Page column 12-13; Sheet 2/4, (2009/04/25)

Functionalized pyridazine derivatives having a low molecular weight and pharmaceutical compositions thereof are useful as alpha-helical mimetics for efficiently disrupting protein-protein interactions such as Bak/Bcl-XL, p53/HDM2, calmodulin/smooth muscle myosin light-chain kinase, and gp41 assembly and for treating conditions and/or disorders mediated by disruption of alpha-helix-binding receptors and proteins.

Synthesis of pyridazines functionalized with amino acid side chains

Mann, Enrique,Moisan, Lionel,Hou, Jun-Li,Rebek Jr., Julius

, p. 903 - 905 (2008/09/17)

A simple route for the preparation of 3,4,6-substituted pyridazines is described by using Tebbe olefination of esters then Diels-Alder reaction of the resulting enol ethers with tetrazine.

Facile Synthesis of Pyridazine-based α-Helix Mimetrics

Moisan, Lionel,Dale, Trevor J.,Gombosuren, Naran,Biros, Shannon M.,Mann, Enrique,Hou, Jun-Li,Crisostomo, Fernando P.,Jr., Julius Rebek

experimental part, p. 661 - 671 (2009/09/28)

The synthesis of an amphiphilic, nonpeptidic scaffold that mimics the presentation of i, i+4, and i+7 residues of an α-helix is presented. The approach uses a pyridazine core, and minimizes the number of C-C bond forming reactions. The synthesis of this Urea-Pyridazine-Piperazine (UPP) scaffold is versatile and its synthesis makes it suitable for the preparationof small libraries of low-molecular-weight α-helix mimetics that can be targeted to specific protein/protein interactions.

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