1007401-61-7Relevant academic research and scientific papers
Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1
Evindar, Ghotas,Deng, Hongfeng,Bernier, Sylvie G.,Doyle, Elisabeth,Lorusso, Jeanine,Morgan, Barry A.,Westlin, William F.
, p. 472 - 475 (2013/02/23)
In the quest to discover a potent and selective class of direct agonists to the sphingosine-1-phosphate receptor, we explored the carboxylate functional group as a replacement to previously reported lead phosphates. This has led to the discovery of potent and selective direct agonists with moderate to substantial in vivo lymphopenia. The previously reported selectivity enhancing moiety (SEM) and selectivity enhancing orientation (SEO) in the phenylamide and phenylimidazole scaffolds were crucial to obtaining selectivity for S1P receptor subtype 1 over 3.
Substituted Aminothiazole Prodrugs of Compounds with Anti-HCV Activity
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, (2009/12/24)
The invention provides amino-substituted aminothiazole compounds of Formula I and Formula II where A is a group of the formula: and the variables X, Y, R, and R1 to R7 are described herein. These compounds are prodrugs of compounds useful as inhibitors of viral replication. Compositions containing such compounds, and methods of treating viral infections with these compounds, as well as to processes and intermediates useful for preparing such compounds are also provided by the invention.
CHEMICAL COMPOUNDS
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Page/Page column 28, (2008/06/13)
The invention provides compounds formula (I), their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system,
