100750-42-3

Basic information

• Product Name: 3-hydroxy-5-phenylthiophene
• Synonyms: 3-hydroxy-5-phenylthiophene
• CAS NO: 100750-42-3
• Molecular Weight: 176.239
• Mol File: 100750-42-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-5-phenylthiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-5-phenylthiophene(100750-42-3)
• EPA Substance Registry System: 3-hydroxy-5-phenylthiophene(100750-42-3)

Safety Data

• Hazardous Substances Data: 100750-42-3(Hazardous Substances Data)

Upstream product

• 72177-12-9 acetic acid-(5-phenyl-[3]thienyl ester) 
• 100750-41-2 (β-carboxymethylsulfanyl-cinnamoylmercapto)-acetic acid 
• 112182-61-3 5-(1-methylsulfanyl-1-phenylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 

Relevant articles and documents

Synthesis of 3-hydroxythiophenes and thiophen-3(2H)-ones by pyrolysis of alkylsulfanylmethylene Meldrum's acid derivatives

3-Hydroxythiophene 1 and a range of its 2-substituted, 2,2-disubstituted and 5-substituted derivatives have been made by flash vacuum pyrolysis (FVP) of an appropriate alkylsulfanylmethylene derivative of Meldrum's acid 3 or 4.These compounds are readily obtained, either by reaction of methoxymethylene Meldrum's acid with alkylthiols in refluxing acetonitrile, or via the bis(methylsulfanyl) compound 18 by known procedures.The pyrolysis proceeds by a hydrogen-transfer-cyclisation mechanism in which thereis extensive loss of configuration of a chiral centre at the reaction site.The NMR and mass spectra of the Meldrum's acid precursors and the mass spectra of the 3-hydroxythiophenes are briefly discussed.