1007528-75-7Relevant academic research and scientific papers
Practical Method for Reductive Deuteration of Ketones with Magnesium and D2O
Bao, Hongli,Li, Yajun,Su, Min,Wan, Wen-Ming,Zhu, Nengbo
, (2020)
α-Deuterated alcohols have important applications in pharmaceuticals and mechanism studies. Here, we report a new and practical strategy for the reductive deuteration of ketones using a Mg/BrCH2CH2Br/D2O system, which affords α-deuterated alcohols in good yields and with almost quantitative incorporation of deuterium. The synthetic value of this method has been demonstrated by the easy access to deuterated drugs or drug derivatives. This method may inspire the discovery of other deuterium-containing drugs.
Site-selective D2O-mediated deuteration of diaryl alcoholsviaquantum dots photocatalysis
Li, Xu-Bing,Nan, Xiao-Lei,Tung, Chen-Ho,Wang, Yao,Wu, Li-Zhu
supporting information, p. 6768 - 6771 (2021/07/13)
Owing to the high synthetic value of deuteration in the pharmaceutical industry, we describe herein the conversion of a range of aromatic ketones to deuterium-labeled products in good to excellent yields. Efficient and site-selective deuteration of benzyl alcohols by D2O with visible light irradiation of quantum dots (QDs), together with gram-scale synthesis and photocatalyst recycling experiments indicated the potential of the developed method in practical organic synthesis.
