1007564-71-7Relevant academic research and scientific papers
Synthesis of thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-ones via their [1,2,4]triazolo[4,3-c]pyrimidine compounds as new ring systems by Dimroth-type rearrangement
Nagamatsu, Tomohisa,Ahmed, Shoeb,Hossion, Abugafar M.L.,Ohno, Seiji
experimental part, p. 777 - 793 (2009/09/25)
General and facile syntheses of thieno|3,2-e||1,2,4|triazolo|1,5-c|-pyrimidin-5(6H)-one (6a) and its 2-substituted derivatives (6b-j) produced by instantaneous isomerization of their |4,3-c| compounds (7a-j), which were prepared by condensation of 4-hydrazinothieno|2,3-d|pyrimidin-2(1/H)-one (10)with appropriate triethyl orthoesters or by oxidative cyclization of 4-(benzylidenehydrazino)thieno|2,3-d|pyrimidin-2(1H)-ones (11c-j), are described as novel ring systems and as a new class of potential xanthine oxidase inhibitors. The |1,5-c| isomers (6a-c) were further prepared by condensation of 3-amino-4-imino-2-oxo-1,2,3,4-tetrahydrothieno|2,3-d|pyrimidine (14) with appropriate triethyl orthoesters as a synthetic method for a reliable structure of the tricyclic ring systems.
