1007566-77-9Relevant academic research and scientific papers
Diastereoselective approach to an HIV protease inhibitor intermediate using a cation-exchange resin mediated Mannich-type reaction
Shimizu, Makoto,Hayashi, Yukinori,Hamanaka, Ryosuke,Hachiya, Iwao
scheme or table, p. 191 - 195 (2009/09/25)
Mannich-type reaction of ketene silyl acetals with a chiral imine proceeded smoothly to give β-amino esters in good yields with high diasetereoselectivity under the influence of a cation-exchange resin, and the subsequent functional group transformations gave an HIV protease inhibitor intermediate. This paper is dedicated to the memory of Professor Ivar Ugi who passed away on 27th September, 2005.
