1007571-75-6Relevant academic research and scientific papers
HETEROCYCLIC ANTIVIRAL COMPOUNDS
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Page/Page column 29, (2009/07/17)
Compounds of formula I, wherein R1, R2, R3, X1, X2 and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase
Sweeney, Zachary K.,Harris, Seth F.,Arora, Nidhi,Javanbakht, Hassan,Li, Yu,Fretland, Jennifer,Davidson, James P.,Billedeau, J. Roland,Gleason, Shelley K.,Hirschfeld, Donald,Kennedy-Smith, Joshua J.,Mirzadegan, Taraneh,Roetz, Ralf,Smith, Mark,Sperry, Sarah,Suh, Judy M.,Wu, Jeffrey,Tsing, Stan,Villase?or, Armando G.,Paul, Amber,Su, Guoping,Heilek, Gabrielle,Hang, Julie Q.,Zhou, Amy S.,Jernelius, Jesper A.,Zang, Fang-Jie,Klumpp, Klaus
experimental part, p. 7449 - 7458 (2010/01/21)
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are recommended components of preferred combination antiretroviral therapies used for the treatment of HIV. These regimens are extremely effective in suppressing virus replication. Structure-based o
Non-nucleoside reverse transcriptase inhibitors
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Page/Page column 36, (2008/06/13)
The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A1, A2, A3 or A4 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.
Non-nucleoside reverse transcriptase inhibitors
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Page/Page column 18, (2009/01/20)
Compounds of formula I, wherein R1, R2, R3, R4, Ra, X, X1, and Y are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
